Department of Chemistry & Biochemistry Seminar Series Presents Dr. David Punihaole

[Natalie Campbell]

Speaker: Dr. David Punihaole, University of Vermont
Talk Date: Wednesday, March 1 st , 2023
Talk time: 12-1 pm
Talk Location: Hudson 106
Post talk reception: In the student common area behind the elevator in
Hudson/Hudson Annex,
2 nd floor. (Food provided)

Title: Towards developing chemical imaging tools to investigate the
molecular etiology of
Alzheimer's Disease

Abstract: Amyloid fibrils are insoluble, non-crystalline protein aggregates
that are commonly
associated with many diseases, such as Alzheimer's Disease and Type II
Diabetes. Amyloid
fibrils are also polymorphic: they differ in molecular structure, how they
grow, self-propagate,
and aggregate. Investigating how different fibril polymorphs aberrantly
interact with their local
biological environment is critical to understanding the clinical variations
observed in patients.
Unfortunately, investigating this is challenging, as there is a lack of
bioanalytical methods to
monitor the dynamics of fibrils directly in cells or biological tissues.
Here, we discuss our
group’s work in addressing this problem. We are developing novel structural
characterization
and chemical imaging tools to monitor the toxic activities of amyloid
fibrils in cellular
environments. Our work lays the foundation to understand the molecular
etiology Alzheimer’s
and other neurodegenerative diseases.

Contact Dr. Glenn Morello with any questions.
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://ls.plattsburgh.edu/pipermail/employee-digest/attachments/20230227/3ee93769/attachment.htm>